Pattern and predictors of immunologic recovery in HIV infected patients
Identifieur interne : 000301 ( Main/Exploration ); précédent : 000300; suivant : 000302Pattern and predictors of immunologic recovery in HIV infected patients
Auteurs : Theophilus B. Kwofie [Ghana] ; Michael Owusu [Ghana] ; Mohamed Mutocheluh [Ghana] ; Samuel Blay Nguah [Ghana] ; Joseph Obeng-Baah [Ghana] ; Charlotte Hanson [Ghana] ; Albert Dompreh [Ghana]Source :
- BMC Research Notes [ 1756-0500 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Agents antiVIH (usage thérapeutique), Analyse multivariée, Charge virale (), Facteurs temps, Femelle, Ghana, Humains, Infections à VIH (immunologie), Infections à VIH (traitement médicamenteux), Infections à VIH (virologie), Interactions hôte-pathogène (), Mâle, Numération des lymphocytes CD4 (), Récupération fonctionnelle (), Récupération fonctionnelle (immunologie), Résultat thérapeutique, VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (physiologie), Valeur prédictive des tests.
- MESH :
- immunologie : Infections à VIH, Récupération fonctionnelle.
- physiologie : VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- traitement médicamenteux : Infections à VIH.
- usage thérapeutique : Agents antiVIH.
- virologie : Infections à VIH.
- Adulte, Adulte d'âge moyen, Analyse multivariée, Charge virale, Facteurs temps, Femelle, Ghana, Humains, Interactions hôte-pathogène, Mâle, Numération des lymphocytes CD4, Récupération fonctionnelle, Résultat thérapeutique, VIH-1 (Virus de l'Immunodéficience Humaine de type 1), Valeur prédictive des tests.
- Wicri :
- geographic : Ghana.
English descriptors
- KwdEn :
- Adult, Anti-HIV Agents (therapeutic use), CD4 Lymphocyte Count (statistics & numerical data), Female, Ghana, HIV Infections (drug therapy), HIV Infections (immunology), HIV Infections (virology), HIV-1 (drug effects), HIV-1 (physiology), Host-Pathogen Interactions (drug effects), Humans, Male, Middle Aged, Multivariate Analysis, Predictive Value of Tests, Recovery of Function (drug effects), Recovery of Function (immunology), Time Factors, Treatment Outcome, Viral Load (drug effects).
- MESH :
- chemical , therapeutic use : Anti-HIV Agents.
- geographic : Ghana.
- drug effects : HIV-1, Host-Pathogen Interactions, Recovery of Function, Viral Load.
- drug therapy : HIV Infections.
- immunology : HIV Infections, Recovery of Function.
- physiology : HIV-1.
- statistics & numerical data : CD4 Lymphocyte Count.
- virology : HIV Infections.
- Adult, Female, Humans, Male, Middle Aged, Multivariate Analysis, Predictive Value of Tests, Time Factors, Treatment Outcome.
Abstract
Although anti-retroviral therapy has generally improved the survival of HIV infected patients in many developing countries including Ghana, specific socio-demographic factors could still influence outcome of treatment. This study was designed to identify patient-specific factors that could influence the immune recovery of absolute CD4 count in HIV infected patients.
Hospital records were extracted from two health facilities in Ghana. The impact of socio-demographic factors type of ART and baseline category of CD4 counts were assessed at six monthly interval using robust linear mixed models.
A total of 214 follow up records were reviewed at Komfo Anokye Teaching Hospital (KATH) and the Kumasi South Hospital (KSH). One hundred (46.7 %) were from KATH and 114 (53.3 %) were from KSH. There was a general increase in the level of CD4 counts with time, however this increase significantly slowed down with subsequent reviews (p < 0.001). On the average the rate of CD4 count recovery slowed down by 43.6 cells/µl for every 6 months of follow up (SE = 7.69; p < 0.001). Similarly the recovery of CD4 counts in subjects with an initial high baseline CD4 counts decreased by 192.6 cells/µl (SD error = 42.3, p value ≤0.001). All other variables were not significantly associated with recovery of CD4 counts.
Our study has demonstrated the well-known phenomenon of CD4 counts increasing after administration of ARTs. CD4 counts increased more rapidly in those with relatively lower initial counts, catching up with those with high CD4 count by 2 years post treatment.
Url:
DOI: 10.1186/s13104-015-1406-3
PubMed: 26341633
PubMed Central: 4560874
Affiliations:
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Le document en format XML
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recovery in HIV infected patients</title><author><name sortKey="Kwofie, Theophilus B" sort="Kwofie, Theophilus B" uniqKey="Kwofie T" first="Theophilus B." last="Kwofie">Theophilus B. Kwofie</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Clinical Microbiology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana</nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea>Department of Clinical Microbiology, Kwame Nkrumah University of Science and Technology, Kumasi</wicri:regionArea><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author><author><name sortKey="Owusu, Michael" sort="Owusu, Michael" uniqKey="Owusu M" first="Michael" last="Owusu">Michael Owusu</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Clinical Microbiology, Komfo Anokye Teaching Hospital, Kumasi, Ghana</nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea>Department of Clinical Microbiology, Komfo Anokye Teaching Hospital, Kumasi</wicri:regionArea><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author><author><name sortKey="Mutocheluh, Mohamed" sort="Mutocheluh, Mohamed" uniqKey="Mutocheluh M" first="Mohamed" 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Baah J" first="Joseph" last="Obeng-Baah">Joseph Obeng-Baah</name><affiliation wicri:level="1"><nlm:aff id="Aff4">Department of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana</nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea>Department of Medicine, Komfo Anokye Teaching Hospital, Kumasi</wicri:regionArea><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author><author><name sortKey="Hanson, Charlotte" sort="Hanson, Charlotte" uniqKey="Hanson C" first="Charlotte" last="Hanson">Charlotte Hanson</name><affiliation wicri:level="1"><nlm:aff id="Aff5">Laboratory Department, Kumasi South Hospital, Kumasi, Ghana</nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea>Laboratory Department, Kumasi South Hospital, Kumasi</wicri:regionArea><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author><author><name sortKey="Dompreh, Albert" sort="Dompreh, Albert" uniqKey="Dompreh A" first="Albert" last="Dompreh">Albert Dompreh</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Clinical Microbiology, Komfo Anokye Teaching Hospital, Kumasi, Ghana</nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea>Department of Clinical Microbiology, Komfo Anokye Teaching Hospital, Kumasi</wicri:regionArea><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author></analytic><series><title level="j">BMC Research Notes</title><idno type="eISSN">1756-0500</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Anti-HIV Agents (therapeutic use)</term><term>CD4 Lymphocyte Count (statistics & numerical data)</term><term>Female</term><term>Ghana</term><term>HIV Infections (drug therapy)</term><term>HIV Infections (immunology)</term><term>HIV Infections (virology)</term><term>HIV-1 (drug effects)</term><term>HIV-1 (physiology)</term><term>Host-Pathogen Interactions (drug effects)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Multivariate Analysis</term><term>Predictive Value of Tests</term><term>Recovery of Function (drug effects)</term><term>Recovery of Function (immunology)</term><term>Time Factors</term><term>Treatment Outcome</term><term>Viral Load (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Agents antiVIH (usage thérapeutique)</term><term>Analyse multivariée</term><term>Charge virale ()</term><term>Facteurs temps</term><term>Femelle</term><term>Ghana</term><term>Humains</term><term>Infections à VIH (immunologie)</term><term>Infections à VIH (traitement médicamenteux)</term><term>Infections à VIH (virologie)</term><term>Interactions hôte-pathogène ()</term><term>Mâle</term><term>Numération des lymphocytes CD4 ()</term><term>Récupération fonctionnelle ()</term><term>Récupération fonctionnelle (immunologie)</term><term>Résultat thérapeutique</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) ()</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (physiologie)</term><term>Valeur prédictive des tests</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-HIV Agents</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Ghana</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>HIV-1</term><term>Host-Pathogen Interactions</term><term>Recovery of Function</term><term>Viral Load</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Infections à VIH</term><term>Récupération fonctionnelle</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>HIV Infections</term><term>Recovery of Function</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>HIV-1</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>CD4 Lymphocyte Count</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à VIH</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Agents antiVIH</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à VIH</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Multivariate Analysis</term><term>Predictive Value of Tests</term><term>Time Factors</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse multivariée</term><term>Charge virale</term><term>Facteurs temps</term><term>Femelle</term><term>Ghana</term><term>Humains</term><term>Interactions hôte-pathogène</term><term>Mâle</term><term>Numération des lymphocytes CD4</term><term>Récupération fonctionnelle</term><term>Résultat thérapeutique</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term><term>Valeur prédictive des tests</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Ghana</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Although anti-retroviral therapy has generally improved the survival of HIV infected patients in many developing countries including Ghana, specific socio-demographic factors could still influence outcome of treatment. This study was designed to identify patient-specific factors that could influence the immune recovery of absolute CD4 count in HIV infected patients.</p></sec><sec><title>Findings</title><p>Hospital records were extracted from two health facilities in Ghana. The impact of socio-demographic factors type of ART and baseline category of CD4 counts were assessed at six monthly interval using robust linear mixed models.</p></sec><sec><title>Results</title><p>A total of 214 follow up records were reviewed at Komfo Anokye Teaching Hospital (KATH) and the Kumasi South Hospital (KSH). One hundred (46.7 %) were from KATH and 114 (53.3 %) were from KSH. There was a general increase in the level of CD4 counts with time, however this increase significantly slowed down with subsequent reviews (p < 0.001). On the average the rate of CD4 count recovery slowed down by 43.6 cells/µl for every 6 months of follow up (SE = 7.69; p < 0.001). Similarly the recovery of CD4 counts in subjects with an initial high baseline CD4 counts decreased by 192.6 cells/µl (SD error = 42.3, p value ≤0.001). All other variables were not significantly associated with recovery of CD4 counts.</p></sec><sec><title>Conclusion</title><p>Our study has demonstrated the well-known phenomenon of CD4 counts increasing after administration of ARTs. CD4 counts increased more rapidly in those with relatively lower initial counts, catching up with those with high CD4 count by 2 years post treatment.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Mermin, J" uniqKey="Mermin J">J Mermin</name></author><author><name sortKey="Were, W" uniqKey="Were W">W Were</name></author><author><name sortKey="Ekwaru, Jp" uniqKey="Ekwaru J">JP Ekwaru</name></author><author><name sortKey="Moore, D" uniqKey="Moore D">D Moore</name></author><author><name sortKey="Downing, R" uniqKey="Downing R">R Downing</name></author><author><name sortKey="Behumbiize, P" uniqKey="Behumbiize P">P Behumbiize</name></author><author><name sortKey="Lule, Jr" uniqKey="Lule J">JR Lule</name></author><author><name sortKey="Coutinho, A" uniqKey="Coutinho A">A Coutinho</name></author><author><name sortKey="Tappero, J" uniqKey="Tappero J">J Tappero</name></author><author><name sortKey="Bunnell, R" uniqKey="Bunnell R">R 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Kindeya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pakker, Ng" uniqKey="Pakker N">NG Pakker</name></author><author><name sortKey="Notermans, Dw" uniqKey="Notermans D">DW Notermans</name></author><author><name sortKey="De Boer, Rj" uniqKey="De Boer R">RJ de Boer</name></author><author><name sortKey="Roos, Mt" uniqKey="Roos M">MT Roos</name></author><author><name sortKey="De Wolf, F" uniqKey="De Wolf F">F de Wolf</name></author><author><name sortKey="Hill, A" uniqKey="Hill A">A Hill</name></author><author><name sortKey="Leonard, Jm" uniqKey="Leonard J">JM Leonard</name></author><author><name sortKey="Danner, Sa" uniqKey="Danner S">SA Danner</name></author><author><name sortKey="Miedema, F" uniqKey="Miedema F">F Miedema</name></author><author><name sortKey="Schellekens, Pt" uniqKey="Schellekens P">PT Schellekens</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Ghana</li></country></list><tree><country name="Ghana"><noRegion><name sortKey="Kwofie, Theophilus B" sort="Kwofie, Theophilus B" uniqKey="Kwofie T" first="Theophilus B." last="Kwofie">Theophilus B. Kwofie</name></noRegion><name sortKey="Dompreh, Albert" sort="Dompreh, Albert" uniqKey="Dompreh A" first="Albert" last="Dompreh">Albert Dompreh</name><name sortKey="Hanson, Charlotte" sort="Hanson, Charlotte" uniqKey="Hanson C" first="Charlotte" last="Hanson">Charlotte Hanson</name><name sortKey="Mutocheluh, Mohamed" sort="Mutocheluh, Mohamed" uniqKey="Mutocheluh M" first="Mohamed" last="Mutocheluh">Mohamed Mutocheluh</name><name sortKey="Nguah, Samuel Blay" sort="Nguah, Samuel Blay" uniqKey="Nguah S" first="Samuel Blay" last="Nguah">Samuel Blay Nguah</name><name sortKey="Obeng Baah, Joseph" sort="Obeng Baah, Joseph" uniqKey="Obeng Baah J" first="Joseph" last="Obeng-Baah">Joseph Obeng-Baah</name><name sortKey="Owusu, Michael" sort="Owusu, Michael" uniqKey="Owusu M" first="Michael" last="Owusu">Michael Owusu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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